Aneuploidy and Drug Resistance in Pathogenic Fungi
نویسندگان
چکیده
منابع مشابه
Aneuploidy and Drug Resistance in Pathogenic Fungi
Genomic imbalance resulting from aneuploidy is detrimental to the proliferation of cells in conditions suitable for normal growth and differentiation [1,2]. However, there is growing evidence that aneuploidy confers a significant growth advantage when cells undergo severe genetic or environmental perturbations [3–6]. For example, aneuploidy restored the ability to proliferate in yeast cells tha...
متن کاملAntifungal resistance in pathogenic fungi.
Pathogenic fungi are the cause of life-threatening infections in an increasing number of immunocompromised patients. The intrinsic resistance to antifungal therapy observed in some genera, along with the development of resistance during treatment in others, is becoming a major problem in the management of these diseases. We reviewed the epidemiology of the most common systemic fungal infections...
متن کاملDrug resistance in fungi – an emerging problem
Over the past quarter of a century, invasive fungal infections have emerged as an important cause of morbidity and mortality in immunocompromised patients. Although several new antifungal drugs have been licensed in recent years, antifungal drug resistance is becoming a major concern during treatment of such patients. The resistance may be intrinsic, acquired or clinical. The understanding of t...
متن کامل[Pleiotropic drug resistance ABC transporters in fungi].
Overexpression of pleiotropic drug resistance (PDR) efflux pumps of the ATP-binding cassette (ABC) transporter superfamily is the major cause of fungal multi-drug resistance and decreased efficacy of antifungal drugs. This review focused on recent progresses in understanding of the PDR efflux pumps of ABC transporter superfamily in Saccharomyces cerevisiae and the fungal pathogens Candida albic...
متن کاملSilicon and plant disease resistance against pathogenic fungi.
Silicon (Si) is a bioactive element associated with beneficial effects on mechanical and physiological properties of plants. Silicon alleviates abiotic and biotic stresses, and increases the resistance of plants to pathogenic fungi. Several studies have suggested that Si activates plant defense mechanisms, yet the exact nature of the interaction between the element and biochemical pathways lead...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS Pathogens
سال: 2012
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.1003022